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Total 393357 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Alouatta | ILX:0100483 | 5 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alouatta caraya | ILX:0100484 | 5 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alouattinae | ILX:0100485 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alpha 3 Acetylcholine Receptor | Neuronal acetylcholine receptor subunit alpha-3 is encoded by the human CHRNA3 gene. This protein plays a role in ion transport. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. (Adapted from NCBI and Swiss-Prot). | ILX:0100486 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha 7 Acetylcholine Receptor | This receptor it a protein that is a translation product of the CHRNA7 gene or a 1:1 ortholog thereof. NACHRA7 is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits. As with other nicotinic acetylcholine receptors, functional α7 receptors are pentameric [i.e., (α7)5 stoichiometry]. It is located in the brain, where activation yields post- and presynaptic excitation, mainly by increased Ca2+ permeability. (Definition provided by PRotein Ontology and Wikipedia). | ILX:0100487 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha Actinin | Cytoskeletal protein present in Z lines of muscle fibrils and at sites of non-muscle cell contact with a substrate (CSP). | ILX:0100488 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha bungarotoxin | A type of bungarotoxin derived from the venom of the Taiwanese cobra Bugarus multicinctus. It is a peptide of 74 amino acids that bind to the nicotinic acetylcholine receptor with high affiniα-bungarotoxinty. | ILX:0100489 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha mating type (yeast) | A S. cerevisiae mating type cells that secrete a pheromone that stimulates haploids. | ILX:0100490 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha synuclein positive inclusion | A cellular inclusion that contains alpha synuclein | ILX:0100491 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha Tanycyte | ILX:0100492 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alpha Tubulin | One of two globular polypeptides forming microtubules. | ILX:0100493 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha wave | an electromagnetic oscillation in the frequency range of 8–12 Hz arising from synchronous and coherent (in phase / constructive) electrical activity. In mammals, thalamic pacemaker cells exhibit alpha oscillations (adapted from Wikipedia). | ILX:0100494 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha-1-proteinase inhibitor | Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation. Pharmacology: Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema. Mechanism of action: Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). It primarily inhibits the action of the serine protease called elastase (also plasmin and thrombin). The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. Drug type: Approved. Biotech. Drug category: Enzyme Replacement Agents | ILX:0100495 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha-ketoglutarate | ILX:0100496 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alpha-Linolenic Acid | Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition. (Wikipedia) Pharmacology: Alpha Linolenic Acid (ALA) is an 18-carbon polyunsaturated fatty acid with three double bonds. It is also called an omega-3 fatty acid, and is essential for all mammals. Alpha-linolenic acid (or omega 3 fatty acid) intake can decrease the risk of cardiovascular diseases by 1) preventing arrhythmias that can lead to sudden cardiac death, 2) decreasing the risk of thrombosis (blood clot formation) that can lead to heart attack or stroke, 3) decreasing serum triglyceride levels, 4) slowing the growth of atherosclerotic plaque, 5) improving vascular endothelial function, 6) lowering blood pressure slightly, and 7) decreasing inflammation. ALA deficiencies can lead to visual problems and sensory neuropathy. Scaly and hemorrhagic skin or scalp inflammations may also develop. Mechanism of action: Alpha Linolenic Acid or ALA is considered an essential fatty acid because it is required for human health, but cannot be synthesized by humans. It is in fact a plant-derived fatty acid. Humans can synthesize other omega-3 fatty acids from ALA, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-inflammatory and anti-atherogenic properties. ALA metabolites may also inhibit the production of the pro-inflammatory eicosanoids, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4), as well as the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Omega-3 fatty acids like ALA and its byproducts can modulate the expression of a number of genes, including those involved with fatty acid metabolism and inflammation. They regulate gene expression through their effects on the activity of transcription factors including NF-kappa B and members of the peroxisome proliferator-activated receptor (PPAR) family. Incorporation of ALA and its metabolites in cell membranes can affect membrane fluidity and may play a role in anti-inflammatory activity, inhibition of platelet aggregation and possibly in anti-proliferative actions of ALA. Drug type: Approved. Nutraceutical. Small Molecule. Drug category: Dietary supplement. Micronutrient | ILX:0100497 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha-melanocyte stimulating hormone | ILX:0100498 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Alpha-Synuclein DNA | The alpha-Synuclein gene is mapped to human chromosome 4q21.3-q22 and organized as seven exons, five of which are protein-coding. | ILX:0100499 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha-Synuclein Fibril | Insoluble fibrils that form in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Alpha-synuclein is the primary structural component. | ILX:0100500 | 6 | scicrunch | 08/24/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Alpha-Synuclein Protein | Predominantly a presynaptic neuronal protein of unknown function, but can also be found in glial cells. Expressed particularly in the neocortex, hippocampus, striatum, thalamus, and cerebellum. It is normally an unstructured protein yet it can aggregate to form incoluble fibrils in pathological conditions characterized by Lewy bodies. It is the primary structural component of Lewy body fibrils and an alpha-synuclein fragment, known as the non-ABeta component (NAC) is found in amyloid plaques. | ILX:0100501 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Alpha-Synuclein RNA | The alpha-Synuclein mRNA is targeted when researchers target alpha-Synuclein gene expression. | ILX:0100502 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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